How to clean the clean room?

How to clean the clean room:

Different ways to clean the clean room:
1, vacuum cleaning
2, using the cleaning tool for wet cleaning
3. Disinfection
4, sterilization
Vacuum cleaning can be done by vacuum cleaning with a centralized vacuum piping system or by a portable automatic vacuum cleaner. Wet cleaning is a widely used method. Dry cleaning is prohibited in the clean room, because particles that fall off from the cleaning tool (rag) during cleaning will fly around and be blown and electrostatically charged. When using wet cleaning, a cleaning tool is used. The purpose of the tool is to peel off the particles from the surface and break down the grease residue. The operation sequence of the wet cleaning will be described below. Disinfection in the biological clean room, disinfection and wet cleaning at the same time. In some cases, spray disinfectant mist into the room air. In aseptic production, it is sometimes necessary to sterilize with a clean room (isolator), that is, to use a gaseous sterilizant (hydrogen peroxide vapor, peracetic acid, formalin, etc.). It should be kept in mind that the purpose of cleaning is to remove the pollution from the clean room rather than moving the pollution from one place to another, and not to carry the pollution out.
Cleaning materials, tools and equipment
Cleaning should be done with washing materials (disinfecting solutions in the medical and pharmaceutical industries), cleaning tools (solution containers, brushes and mops) and materials (cloth rags for different purposes, microporous sponges). Wood cleaning tools shall not be used. All tools and equipment shall be clean and replaced with new ones. Damaged tools or tools with scratched notches and other damage shall not be used. Cleaning tools shall be marked with the use of the property.
barrel
Stainless steel or plastic drums should be used. Pay attention to the integrity of the barrel, especially plastic drums, which are prone to cracks and scratches.
Mop and sponge
The mop is used to clean the walls and floors. The mop with the water squeezing device has a sponge inside. The sponge used for cleaning the ISO5 or above clean room should always be in a damp state. The sponge should be inspected for fracture before use because the fracture will become a source of particle divergence. Other structures of mops can also be used.
Roller
Clean the surface of the clean room with the same adhesive layer as the Dycem floor. The roller can be used to easily clean the plane between the filter and the wall. After the roller is used, it should be cleaned and dried with cleaning materials and disinfectant.
brush
The brush is an unwelcome thing in the clean room in terms of its natural characteristics. It has a lot of voids to retain dirt, but in many cases it is not enough to lack it. Brushes can be used with large dirt (crushed glass), hard-to-reach parts and holes, etc. It is forbidden to use a bristle brush. Plastic brushes with plastic fibers should be used.
rag
It is necessary to use a rag to clean the surface according to the purpose of the clean room.
The surface of the clean room being used, during installation and ready for production; wiping of tools; wiping of computer and instrument screens; wiping of equipment.
The requirements for the rag are as follows:
(1) determining that non-divergent dust particles include both liquid and solid;
(2) Strictly of the same nature, containing no unwanted impurities that contaminate the clean room or damage the surface;
(3) high cleanliness;
(4) Fast
(5) water absorption;
(6) It is suitable for disinfection (if necessary).
Cleaning equipment for clean rooms
At present, in various industries, including microelectronics and medical care, a wide range of special tools for cleaning clean rooms are widely used, including trolleys (for handling cleaning and disinfecting liquids), mops with clips (clamping sponges, special fabrics, etc.), rags. Wait.
Vacuum cleaners require a vacuum cleaner for the clean room. Sometimes a centralized vacuum dedusting system can be used to establish a vacuum pipe network, and the connection points are set in the clean room. The clean room can be cleaned initially and used to remove residual moisture after wet cleaning before wet cleaning.
Cleaning process
Cleaning should meet the following three requirements:
(1) Start from the clean area (near the HEPA filter) and advance to the dirty part (row grille and door, floor);
The cleaning should be carried out in parallel with each other, and the detachment of the rag (mound) should be lifted off the surface to restart the new movement. (2) Do not round or move back and forth on the surface.
(3) The vertical or inclined surface should be cleaned from top to bottom. When cleaning and disinfecting the clean room, arrange the necessary time to prepare the necessary tools and articles. If using a rag, the washing liquid should be sprinkled on the rag and should not be sprinkled on the cleaned surface.
Pay special attention to the horizontal surface during cleaning. The mistake in cleaning is to move the dirt from one place to another instead of cleaning it from the surface. A variety of cleaning methods are available: daily, regular and large cleaning. Every day and night (per shift) or after each batch of product is manufactured, 1-2 daily cleanings should be performed. Regular cleaning can be done once a week (monthly). Thorough cleaning on a monthly or quarterly basis can be determined on a case-by-case basis. These data are not dogmatic, and each company can develop its own cleaning rules based on the level of cleanliness, the nature of the production and the product.
After the installation, commissioning and commissioning of the clean room are completed, special attention should be paid to the clean room to be cleaned multiple times before the inspection and certification. In the daily cleaning, the floor can be cleaned by liquid method. Injectors and disinfectant injectors, etc., should increase the workload during regular cleaning. It is necessary to clean the walls, furniture, and some parts of the equipment. The cleaning should include cleaning all the cleaning rooms and equipment and thoroughly and thoroughly.
The complete cleaning procedure is as follows:
1. Prepare to clean and disinfect (re-clean) the solution. It can be used as a common cleaning solution that does not damage the surface layer of the clean room. Some surface layers are easily damaged, such as the inability to withstand hydrogen peroxide. The solution for the clean room should be prepared with deionized water. In the sterilization process, pure water or water for injection filtered through a 0.22 micron filter is used.
2. The requirements for personnel entering the clean room for cleaning are the same as those for entering the clean room for long-term rollers.
3. Apply a brush to the visible dirt (broken glass, etc.), rub it, and wipe it carefully. Do not spread dirt.
4. Ceiling: Clean the ceiling with a wet rag or adhesive roller, but be careful not to damage the HEPA filter. If the ceiling is all HEPA filter, do not touch it to ensure the ventilation system works normally. If necessary, clean the fixings (frames) between the filters and use a rag, roller or vacuum cleaner to move in one direction.
5, wall: wet cleaning with mops, rollers or rags, should be covered in parallel with each other, moving from top to bottom, pay special attention to switches, sockets and signaling devices.
6. Glass surface: The cleaning method is the same as the wall. Sprinkle some alcohol solution during cleaning (if it is sterilized, use a formalin solution filtered through a 0.22 micron filter).
7. Floor: The cleaning method is the same as the wall. It should be parallel to each other and move from the center to the door. Frequently, the sponge should be rinsed in a bucket with solution (after each movement) using a mop with a sponge clamp. More convenient.
8. In order to have sterilized production conditions, the cleaning room should be sterilized after the cleaning is completed, and formalin can be sterilized. For this purpose, a hydrogen peroxide sprayer or other tools should be used, and the steam should be cleaned. Stay indoors for hours, such as 24 hours. After this disinfection is completed, it is sometimes necessary to repeat the disinfection of individual surfaces of the clean room.
9. After the cleaning of the clean room is completed, clean the locker room, the material air lock chamber and the furniture in it, pay special attention to the wash basin, the faucet, the injector, and its vicinity.
10. Check the air and surface cleanliness after cleaning.
11. Record should be made on the cleaning diary, indicating the type of cleaning, time and name of the performer. After the cleaning work is completed, the cleanliness of each surface of the clean room should be checked. The most widely used inspection methods are:
(a) Check with a rag to find larger particles. This method is simple, intuitive, and effective in many cases and can be divided into two methods:
Check with a white rag, wipe the surface with a rag, check for dirt under the light; check with a black rag and compare it to a white rag; check with white light and slant the surface with a strong light in a dark room to see if A shadow of particles that settle on the surface. And the difference in color between the clean surface and the contaminated surface.
(b) Irradiation with ultraviolet light is carried out in a dark room, and ultraviolet rays (365 nm) cause multi-organic matter to emit light.
(c) The surface was examined by an optical microscope to find particles having a particle diameter of 5 μm or more.
(d) Particle counting is performed on the sediment on the sheet using a microscope or a laser particle counter.
(e) Scan the surface with a dedicated instrument.